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Human randomized trial / 2023

Triple-Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial

Jastreboff AM, Kaplan LM, Frías JP, et al.

Study overview

This placebo-controlled phase 2 trial followed 338 adults for 48 weeks. The investigational receptor agonist produced weight reduction across treatment groups; gastrointestinal events and increases in heart rate were reported.

Results are specific to the study. This is an editorial summary, not personal treatment advice.

Study limitations

A phase 2 result does not establish long-term safety, outcomes in excluded groups, or regulatory approval. This record describes the 2023 publication, not a current regulatory-status assessment.

About this summary

This summary uses the cited abstract and bibliographic record. Read the original methods and results for the full context.

Read original study

DOI: 10.1056/NEJMoa2301972

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